Publications

The LTB continues its support of the OSU Comprehensive Cancer Center mission to be on the forefront of improving existing patient therapies by supporting carefully designed, innovative research and clinical studies. Listed here are research studies which were supported by the OSUCCC Leukemia Tissue Bank Shared Resource.

Wang L, Wang J, Blaser BW, Duchemin AM, Kusewitt DF , Liu T, Caligiuri MA, Briesewitz R. Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia. Blood 2007 Sep 15; 110(6): 2075-83.

Chang JS, Santhanam R, Trotta R, Neviani P, Eiring AM, Briercheck E, Ronchetti M, Roy DC, Calabretta B, Caligiuri MA, Perrotti D . High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C/EBP{alpha}-driven myeloid differentiation. Blood. 2007 Aug 1; 110(3):994-1003.

Caligiuri MA, Briesewitz R , Yu J, Wang L, Wei M, Arnoczky KJ, Marburger TB, Wen J, Perrotti D, Bloomfield CD, Whitman SP . Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia. Blood. 2007 Aug 1; 110(3):1022-4.

Pal S, Baiocchi RA , Byrd JC, Grever MR, Jacob ST , Sif S . Low levels of miR-92b/96 induce RMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma. EMBO J. 2007 Aug 8; 26(15): 3558-69.

Otterson GA, Villalona-Calero MA, Sharma S, Kris MG, Imondi, A, Gerber M, White DA, Ratain MJ, Schiller JH, Sandler A, Kraut M, Mani S, Murren JR, Phase I study of inhaled Doxorubicin for patients with metastatic tumors to the lungs. Clin Cancer Res. 2007 Feb 15; 13(4):1246-52.

Khan KD, Emmanouilides C, Benson DM Jr, Hurst D, Garcia P, Michelson G, Milan S, Ferketich AK, Piro L, Leonard JP, Porcu P , Eisenbeis CF, Banks AL, Chen L, Byrd JC, Caligiuri MA . A phase 2 study of rituximab in combination with recombinant interleukin-2 for rituximab-refractory indolent non-Hodgkin's lymphoma. Clin Cancer Res. 2006 Dec 1; 12(23):7046-53.

Shah MH, Freud AG, Benson DM Jr. Ferketich AK , Dezube BJ, Berstein ZP, Caligiuri MA. A phase I study of ultra low dose interleukin-2 and stem cell factor in patients with HIV infection or HIV and cancer. Clin. Cancer Res. 2006 Jul. 1; 12(13): 3993-6.

Mrozek E, Kloos RT , Ringel MD , Kresty L , Snider P, Arbogast D, Kies M. Munden R, Busaidy N, Klein MJ, Sherman SI, Shah MH . Phase II study of celecoxib in metastatic differentiated thyroid carcinoma. J. Clin. Endocrinol. Metab. 2006 Jun; 91(6):2001-4.

Radmacher MD, Marcucci G , Ruppert AS, Mrozek K , Whitman SP , Vardiman JW, Paschka P, Vukosavljevic T, Baldus CD, Kolitz JE, Caligiuri MA , Larson RA, Bloomfield CD. Independent confirmation of prognostic gene expression signature in adult acute myeloid leukemia with a normal karyotype: A Cancer and Leukemia Group B Study. Blood 2006 May 2

Magro CM, Nash JW, Werling RW, Porcu P , Crowson N. Primary Cutaneous CD30+ large cell B-cell lymphoma: a series of 10 cases. Appl Immunohistochem Mol Morphol. 2006 Mar; 14(1):7-11.

Mone A, Puhalla S, Whitman, S , Baiocchi R , Cruz J, Vukosavlevic T, Banks A, Eisenbeis C , Byrd JC , Caligiuri M, Porcu P . Durable hematological complete response and suppression of HTLV-1 viral load following alemtuzumab in AZT/IFN{alpha} -refractory adult T-cell leukemia. Blood 2005 Nov 15; 106(10):3380-2.

Whitman SP , Liu S , Vukosavljevic T , Rush LJ , Yu L , Liu C , Klisovic MI , Maharry K , Guimond M , Strout MP , Becknell B , Dorrance A , Klisovic RB , Plass C , Bloomfield CD , Marcucci G , Caligiuri MA . The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy. Blood. 2005 Jul 1; 106(1):345-52.

Gore SD , Smith BD , Gojo I , Grever M , Kaufmann SH , Letendre L , Leonard DG , Marcucci G , Miller CB , Morris L , Piantadosi S , Prior T , Stock W , Karp JE . Durable molecular remissions with a single cycle of timed sequential consolidation chemotherapy in acute promyelocytic leukemia. Am J Hematol. 2005 Jun; 79(2):119-27.

Marcucci G , Stock W , Dai G , Klisovic RB , Liu S , Klisovic MI , Blum W , Kefauver C , Sher DA , Green M , Moran M , Maharry K , Novick S , Bloomfield CD, Zwiebel JA , Larson RA , Grever MR , Chan KK , Byrd JC . Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: pharmacokinetics, pharmacodynamics, and clinical activity. J Clin Oncol. 2005 May 20; 23(15):3404-11.

Dai G , Chan KK , Liu S , Hoyt D , Whitman SP , Klisovic M , Shen T , Caligiuri MA , Byrd J , Grever M , Marcucci G ., Ce llular uptake and intracellular levels of the bcl-2 antisense g3139 in cultured cells and treated patients with acute myeloid leukemia. Clin Cancer Res. 2005 Apr 15; 11(8):2998-3008.

Shah MH , Young D , Kindler HL , Webb I , Kleiber B , Wright J , Grever M ., Phase II study of the proteasome inhibitor bortezomib (PS-341) in patients with metastatic neuroendocrine tumors. .Clin Cancer Res. 2004 Sep 15; 10(18 Pt 1):6111-8.

Eisenbeis CF , Grainger A , Fischer B , Baiocchi RA , Carrodeguas L , Roychowdhury S , Chen L , Banks AL , Davis T , Young D , Kelbick N , Stephens J , Byrd JC , Grever MR , Caligiuri MA , Porcu P Combination immunotherapy of B-cell non-Hodgkin's lymphoma with rituximab and interleukin-2: a preclinical and phase I study. Clin Cancer Res. 2004 Sep 15; 10(18 Pt 1):6101-10.

Marcucci G , Stock W , Dai G , Klisovic MI , Maharry K , Shen T , Liu S , Sher DA , Lucas D , Zwiebel A , Larson RA , Caligiuri MA , Bloomfield CD , Chan KK , Grever MR , Byrd JC . G3139, a BCL-2 antisense oligo-nucleotide, in AML. Ann Hematol. 2004; 83 Suppl 1:S93-4.

Cosio FG , Nuovo GJ , Delgado L , Yearsley M , Porcu P , Caligiuri MA , Pelletier RP , Nuovo GJ . EBV kidney allograft infection: possible relationship with a peri-graft localization of PTLD Am J Transplant. 2004 Jan; 4(1):116-.23.

Porcu P , Baiocchi RA , Magro C ., Recent developments in the biology and therapy of T-cell and natural killer-cell lymphomas. Curr Opin Oncol. 2003 Sep; 15(5):353-62.

Shah MH , Porcu P , Mallery SR , Caligiuri MA AIDS-associated malignancies. Cancer Chemother Biol Response Modif. 2003; 21:717-46.

Griffin JH, Leung J, Bruner RJ, Caligiuri MA, Briesewitz R. Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7830-5. Epub 2003 Jun 13

Baldus CD, Tanner SM, Ruppert AS, Whitman SP , Archer KJ, Marcucci G, Caligiuri MA, Carrol AJ, Vardiman JW, Powell BL, Allen SL, Moore JO, Larson RA, Kolitz JE, de la Chapelle A, Bloomfield CD. BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: a Cancer and Leukemia Group B Study. Blood. 2003 Sep 1; 102(5):1613-8. Epub 2003 May 15.

Roychowdhury S, Peng R, Baiocchi RA , Bhatt D, Vourganti S, Grecula J, Gupta N, Eisenbeis CF , Nuovo GJ , Yang W, Schmalbrock P, Ferketich A , Moeschberger M , Porcu P, Barth RF, Caligiuri MA. Experimental treatment of Epstein-Barr virus-associated primary central nervous system lymphoma. Cancer Res. 2003 Mar 1; 63(5):965-71

Klisovic MI, Maghraby EA, Parthun MR, Guimond M, Sklenar AR, Whitman SP, Chan KK , Murphy T, Anon J, Archer KJ, Rush LJ , Plass C, Grever MR, Byrd JC, Marcucci G. Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells. Leukemia. 2003 Feb; 17(2):350-8.

Ladner KJ, Caligiuri MA, Guttridge DC . Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products. J Biol Chem. 2003 Jan 24; 278(4):2294-303.

Marcucci G, Byrd JC , Dai G, Klisovic MI, Kourlas PJ, Young DC, Cataland SR, Fisher DB, Lucas D, Chan KK , Porcu P, Lin ZP, Farag SF , Frankel SR, Zwiebel JA, Kraut EH, Balcerzak SP, Bloomfield CD, Grever MR, Caligiuri MA . Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia. Blood. 2003 Jan 15; 101(2):425-32. Epub 2002 Aug 22.

Shah MH, Porcu P, Mallery SR, Caligiuri MA . AIDS-associated malignancies. Cancer Chemother Biol Response Modif. 2002; 20:633-64. Review. No abstract available

Porcu P, Eisenbeis CF , Pelletier RP, Davies EA, Baiocchi RA, Roychowdhury S, Vourganti S, Nuovo GJ , Marsh WL, Ferketich AK , Henry ML, Ferguson RM, Caligiuri MA. Successful treatment of posttransplantation lymphoproliferative disorder (PTLD) following renal allografting is associated with sustained CD8 (+) T-cell restoration. Blood. 2002 Oct 1; 100(7):2341-8

Whitman SP , Archer KJ, Feng L, Baldus C, Becknell B, Carlson BD, Carroll AJ, M rozek K, Vardiman JW, George SL, Kolitz JE, Larson RA, Bloomfield CD, Caligiuri MA. Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study. Cancer Res. 2001 Oct 1; 61(19):7233-9.

Baiocchi RA , Ward JS, Carrodeguas L, Eisenbeis CF, Peng R, Roychowdhury S, Vourganti S, Sekula T, O'Brien M, Moschberger M, Caligiuri MA . GM-CSF and IL-2 induce specific cellular immunity and provide protection against Epstein-Barr virus lymphoproliferative disorder. J Clin Invest. 2001 Sep; 108(6):887-94

Marcucci G, Caligiuri Ma, Dohner H, Archer KJ, Schlenk RK, Dohner K, Maghraby EA, Bloomfield CD . Quantification of CBFbeta/MYH11 fusion transcript by real time RT-PCR in patients with INV (16) acute myeloid leukemia. Leukemia. 2001 Jul; 15(7):1072-80.

Reuther GW, Lambert QT, Booben MA, Wennerberg K, Becknell B, Marcucci G , Sondek J, Caligiuri MA, Der CJ. Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA. J Biol Chem. 2001 Jul 20; 276(29):27145-51. Epub 2001 May 23

Nuovo GJ , Morrison C, Porcu, P, Caligiuri MA, Suster S. In situ determination of T-cell receptor beta expression patterns. J Histochem Cytochem. 2001 Feb; 49(2):139-45.

Whitman SP , Strout MP, Marcucci G , Freud AG, Cully LL, Zeleznik-Le NJ, Mrozek K, Theil KS, Kees UR, Bloomfield CD, Caligiuri MA . The partial nontandem duplication of the MLL (ALL1) gene is a novel rearrangement that generates three distinct fusion transcripts in B-cell acute lymphoblastic leukemia. Cancer Res. 2001 Jan 1; 61(1):59-63.

Yang J, Tao Q, Flinn IW, Murray PG, Post LE, Ma H, Piantadosi S, Caligiuri MA, Ambinder RF. Characterization of Epstein-Barr virus-infected B cells in patients with posttransplantation lymphoproliferative disease: disappearance after rituximab therapy does not predict clinical response. Blood. 2000 Dec 15; 96(13):4055-63.

Porcu, PG, Caligiuri MA . Acquired immunodeficiency syndrome-related lymphomas: future directions. Semin Oncol. 2000.

Shah, MH, Baiocchi RA , Fehniger, TA, Khatri, VP, Gould, M. Poiesz, B, Berstein, ZP, Caligiuri MA Cytokine replacement in patients with HIV-1 non-Hodgkin's lymphoma: the rationale for low-dose interleukin-2 therapy. Cancer J Sci Am. 2000 Feb; 6 Suppl 1:S45-51. Review.

Baiocchi, RA, Caligiuri MA. Cytokines in the evolution and treatment of AIDS-lymphoma. Curr Opin Oncol. 1999 Nov; 11(6):516-21. Review.

Fehniger TA, Herbein G, Yu, H, Para MI, Berstein, ZP, O'Brien, WA, Caligiuri MA. Natural killer cells from HIV-1+ patients produce C-C chemokines and inhibit HIV-1 infection. J Immunol. 1998 Dec 1; 161(11):6433-8.