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Quantitaion of a compound can begin once an analyticalmethod has been
developed. Using validated method procedures, samples containing
unknown concentrations of a compound will be processed by PhASR staff
and analyzed on the PhASR LC/MS equipment. Samples may arise from
biological matrices such as plasma, urine or feces, or they may come
from in vitro systems. The validity of results is ensured by
1) the method validation process, 2) processing quality control
samples, and 3) standard samples, all processed and analyzed in
parallel to the unknown samples. Once a run is complete, the PhASR will
review the data to ensure all QCs fell within the allowed range of
accuracy and the measured standard sample concentrations produce a
linear range for quantitation. If the pre-established quality controls
are not met, PhASR staff will repeat the run, making any adjustments
necessary to further ensure accuracy and precision.
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