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This service establishes a unique quality of the PhASR for OSUCCC
researchers. Clinical and pre-clinical research involving experimental
therapeutics requires an understanding of the fate of the drug and/or
its metabolites in a biological system. This understanding can be
achieved by the proper design of a pharmacokinetic sampling strategy to
obtain representative biological specimens before, during and after
drug administration. Once obtained, samples must also be processed and
stored appropriately to ensure specimens remain representative of the
biological samples that were originally obtained. The PhASR works
closely with the Clinical Treatment Unit (CTU) to advise on sampling
and storage strategies that will provide the highest quality data while
considering the needs of the patient and CTU procedures. Similarly, the
PhASR will help to design and consult on pharmacokinetic sampling and
specimen preparation strategies for preclinical and basic research.
After samples have been analyzed, the PhASR staff will complete an
analysis of the data generated. This analysis may be as simple as
non-compartmental analysis, or it may include more complex modeling
with simulation with alternative dose levels or correlation with
pharmacodynamic data. Overall, users will have full access to the
PhASR's expertise in pharmacokinetics before, during and after a
project is initiated.
SERVICE REQUEST
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