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Quantitation
of a compound can begin once an analytical method has been developed.
Using validated method procedures, samples containing unknown
concentrations of a compound will be processed by PhASR staff and
analyzed on the PhASR LC/MS equipment. Samples may arise from
biological matrices, such as plasma, urine or feces, or they may come
from in vitro systems. The validity of results is ensured by 1) the
method validation process, 2) processing quality control samples, and
3) standard samples, all processed and analyzed in parallel to the
unknown samples. Once a run is complete, the PhASR will review the data
to ensure all QCs fell within the allowed range of accuracy and the
measured standard sample concentrations produce a linear range for
quantitation. If the pre-established quality controls are not met,
PhASR staff will repeat the run, making any adjustments necessary to
further ensure accuracy and precision. SERVICE REQUEST
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