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The Ohio State University Comprehensive Cancer Center
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Research Programs


Experimental Therapeutics

This program comprises three thematic areas that are aligned with one overall goal: to lower the cancer cell's threshold for apoptosis, or natural cell death, thus promoting the biological destruction of cancer. Experimental Therapeutics members are focused on understanding: 1) the mechanisms by which epigenetic alterations contribute to the genesis and chemoresistance of cancer, and how such alterations can be exploited clinically; 2) how monoclonal antibody therapy can be used to enhance cell susceptibility to cancer chemotherapy; and 3) how novel chemotherapeutic combinations can target survival and chemotherapy resistance pathways in the cancer cell. These themes require strong interprogrammitic collaboration that has led to a substantial increase in interactive grants, clinical protocols and publications in scientific journals.

Program Leaders

     

Michael R. Grever, M.D.

Professor/ Chair
Internal Medicine
215 Means Hall
1654 Upham Drive Columbus,OH. 43210

 

o

(614) 293-8724

f

(614) 293-6656
michael.grever@osumc.edu
 
     

Samson T. Jacob, Ph.D.

Professor
Molecular and Cellular Biochemistry
333 Hamilton Hall
1645 Neil Avenue Columbus,OH. 43210

 

o

(614) 688-5494

f

(614) 688-5600
jacob.42@osu.edu
 

Program Members

     

Rolf F. Barth, M.D.

Professor
Pathology
165 Hamilton Hall
1645 Neil Avenue Columbus,OH. 43210

 

o

(614) 292-2177

f

(614) 292-7072
rolf.barth@osumc.edu
 
     

Sujit Basu, M.D., Ph.D.

Assoc Professor
Pathology
166 Hamilton Hall
1645 Neil Ave Columbus,OH. 43210

 

o

(614) 247-5414

f

(614) 247 5406
Sujit.Basu@osumc.edu
 
     

Tanios S. Bekaii-Saab, M.D.

Asst Professor
Internal Medicine
Starling Loving
320 W. 10th Avenue Columbus,OH. 43210

 

o

(614) 293-8620

f

(614) 293-4372
tanios.bekaii-saab@osumc.edu
 
     

Roger Briesewitz, Ph.D.

Asst Professor
Pharmacology
5130 Graves Hall
333 W 10th Ave Columbus,OH. 43210

 

o

(614) 292-8608

f

(614) 292-7232
Briesewitz.1@osu.edu
 
     

John C. Byrd, M.D.

Professor
Internal Medicine
B302 Starling-Loving
320 W. 10th Avenue Columbus,OH. 43210

 

o

(614) 293-7509

f

(614) 293-7526
john.byrd@osumc.edu

 

Other Programs:

Innate Immunity
     

Arnab Chakravarti, M.D.

Chair
Radiation
080 B James Cancer Hosp & Res Inst
300 W 10th Ave Columbus,OH. 43210

 

o

(614) 366-4671

f

chakravarti.7@osu.edu
 
     

Jeffrey J. Chalmers, Ph.D.

Professor
Chemical & Biomolecular Engineering
121 Koffolt Laboratories
140 W. 19th Avenue Columbus,OH. 43210

 

o

(614) 292-2727

f

(614) 292-3769
chalmers@che.eng.ohio-state.edu
 
     

Kenneth K. Chan, Ph.D.

Professor
Pharmacy
308 OSUCCC
410 W. 12th Avenue Columbus,OH. 43210

 

o

(614) 292-8294

f

(614) 292-7766
chan.56@osu.edu
 
     

Larry J. Copeland, M.D.

Professor
Obstetrics & Gynecology
505 Means Hall
1654 Upham Drive Columbus,OH. 43210

 

o

(614) 293-8697

f

(614) 293-5877
larry.copeland@osumc.edu
 
     

Steven M. Devine, M.D.

Assoc Professor
Internal Medicine
B316 Starling/Loving
320 W 10th Ave Columbus,OH. 43210

 

o

(614) 293-6794

f

(614) 293-6690
steven.devine@osumc.edu
 
     

Wenrui Duan, Ph.D.

Research Scientist
Comprehensive Cancer Center
1230 James Cancer Hospital
300 W 10th Ave. Columbus,OH. 43210

 

o

(614) 293-3235

f

wenrui.duan@osumc.edu
 
     

Michael A. Freitas, Ph.D.

Research Asst Professor
Molecular Virology, Immunology & Medical Genetics
0044a MP newman & WLF
100 W 18th Ave Columbus,OH. 43210

 

o

(614) 688-8432

f

(614) 292-0559
freitas.5@osu.edu
 
     

Kalpana Ghoshal, Ph.D.

Research Asst Professor
Molecular and Cellular Biochemistry
319 Hamilton Hall
1645 Neil Avenue Columbus,OH. 43210

 

o

(614) 292-8865

f

(614) 292-4118
ghoshal.1@osu.edu
 
     

John C Grecula, M.D.

Assoc Professor
Radiology
070B James Cancer
300 W. 10th Avenue Columbus,OH. 43210

 

o

(614) 293-8415

f

john.grecula@osumc.edu
 
     

Howard H Gu, Ph.D.

Assoc Professor
Pharmacology & Psychiatry
5184B Graves Hall
333 West 10th Avenue Columbus,OH. 43210

 

o

(614) 292-1324

f

(614) 292-7232
gu.37@osu.edu
 
     

Nathan C Hall, M.D., Ph.D.

Asst Professor
Radiology
Suite 432
395 West 12th Ave Columbus,OH. 43210

 

o

(614) 293-2788

f

(614) 293-9275
nathan.hall@osumc.edu
 
     

Nyla A. Heerema, Ph.D.

Professor
Pathology
129 Hamilton Hall
1645 Neil Avenue Columbus,OH. 43210

 

o

(614) 292-7815

f

(614) 293-9919
nyla.heerema@osumc.edu
 
     

Richard T. Kloos, M.D.

Cl Professor
Internal Medicine
446 McCampbell Hall
1581 Dood Drive Columbus,OH. 432101296

 

o

(614) 292-3800

f

(614) 292-1550
richard.kloos@osumc.edu
 
     

Michael V. Knopp, M.D., Ph.D.

Professor
Radiology
657 Means Hall
1654 Upham Drive Columbus,OH. 43210

 

o

(614) 293-9998

f

(614) 293-9275
michael.knopp@osumc.edu
 
     

Eric H. Kraut, M.D.

Professor
Internal Medicine
A434B Starling Loving
320 W. 10th Avenue Columbus,OH. 43210

 

o

(614) 293-8726

f

(614) 293-7525
eric.kraut@osumc.edu
 
     

Periannan Kuppusamy, Ph.D.

Professor
Internal Medicine
114 Tzagournis Medical Research Facilty
420 W. 12th Avenue Columbus,OH. 43210

 

o

(614) 292-8998

f

(614) 292-8454
periannan.kuppusamy@osumc.edu
 
     

Mamuka Kvaratskhelia, Ph.D.

Assoc Professor
Pharmacy
238 Parks Hall
500 West 12th Avenue Columbus,OH. 43210

 

o

(614) 292-6091

f

(614) 292-7766
Kvaratskhelia.1@osu.edu
 
     

Robert J. Lee, Ph.D.

Assoc Professor
Pharmacy
542 Parks Hall
500 W. 12th Avenue Columbus,OH. 43210

 

o

(614) 292-4172

f

(614) 292-7766
lee@pharmacy.ohio-state.edu
 
     

Chenglong Li, Ph.D.

Asst Professor
Medicinal Chemistry
612 Riffe Building
496 W 12th Ave Columbus,OH. 43210

 

o

(614) 247-8786

f

(614) 292-2435
li.728@osu.edu
 
     

Jiayuh Lin, Ph.D.

Assoc Professor
Pediatrics
WA5020 Center for Childhood Cancer - CCRI
700 Children's Drive Columbus,OH. 43205

 

o

(614) 722-5086

f

(614) 722-5868
Jiayuh.Lin@nationwidechildrens.org
 
     

David M Lucas, Ph.D.

Asst Professor
Internal Medicine
455D
410 W 12th Ave Columbus,OH. 43210

 

o

(614) 292-8154

f

david.lucas@osumc.edu
 
     

Guido Marcucci, M.D.

Assoc Professor
Internal Medicine
898 BRT
460 W. 12th Ave Columbus,OH. 43210

 

o

(614) 366-2261

f

(614) 688-4028
guido.marcucci@osumc.edu
 
     

Nina A. Mayr, M.D.

Professor
Radiation Medicine
88B James Cancer Hospital
300 W. 10th Ave. Columbus,OH. 43210

 

o

(614) 293-3244

f

nina.mayr@osumc.edu
 
     

Ehud Mendel, M.D., FACS

Professor
Neurological Surgery
N1025 Doan Hall
410 West 10th Avenue Columbus,OH. 43210

 

o

(614) 293-5346

f

(614) 293-4024
ehud.mendel@osumc.edu
 
     

Ichiro Nakano, M.D., Ph.D.

Assoc Professor
Neurological Surgery
385A Wiseman Hall
400 W 12th Ave Columbus,OH. 43210

 

o

(614) 292-0358

f

(614) 688-4882
Ichiro.Nakano@osumc.edu
 
     

David M. O'Malley, M.D.

Asst Professor
Obstetrics & Gynecology
Means 210
320 W 10th Ave Columbus,OH. 43210

 

o

(614) 293-3145

f

david.o'malley@osumc.edu
 
     

Quintin Pan, Ph.D.

Assoc Professor
Otolaryngology
Suite 4A Cramblett
456 W 10th Ave Columbus,OH. 43210

 

o

(614) 247-4438

f

Quintin.Pan@osumc.edu
 
     

Mark R. Parthun, Ph.D.

Assoc Professor
Molecular and Cellular Biochemistry
411 Hamilton Hall
1645 Neil Avenue Columbus,OH. 43210

 

o

(614) 292-6215

f

(614) 292-4118
Parthun.1@osu.edu
 
     

Tushar Patel, M.B., ChB

Professor
Internal Medicine
200 North Doan Tower
395 West 10th Avenue Columbus,OH. 43210

 

o

(614) 366-4748

f

(614) 293-0861
Tushar.Patel@osumc.edu
 
     

Philip R. Payne, Ph.D.

Asst Professor
Biomedical Informatics
3190 Graves Hall
333 West 10th Avenue Columbus,OH. 43210

 

o

(614) 292-4778

f

(61) 688-6600
philip.payne@osumc.edu
 
     

John P. Perentesis, M.D., FAAP

Professor/ Director
Pediatrics
CHRF-2372 Mail Location 7015
3333 Burnet Ave Cincinnati,OH. 45229

 

o

(513) 636-6090

f

(513) 636-3549
John.Perentesis@cchmc.org
 
     

Allen Mitchell Phelps, Ph.D.

Assistant Prof
228 Parks Hall
500 W 12th Ave Columbus,OH. 43210

 

o

(614) 688-4370

f

phelps.32@osu.edu
 
     

Christopher R Pierson, M.D., Ph.D.

Asst Professor
Pathology
WA5016
700 Childrens Dr. Columbus,OH. 43205
 
     

Stephen P. Povoski, M.D.

Assoc Professor
Surgery
N-924 Doan Hall
410 West 10th Ave Columbus,OH. 43210

 

o

(614) 293-8700

f

(614) 293-3465
stephen.povoski@osumc.edu
 
     

Frederick K Racke, M.D., Ph.D.

Assoc Professor
Pathology
S301 Rhodes Hall
450 W. 10th Ave. Columbus,OH. 43210

 

o

(614) 366-2467

f

(614) 293-2075
frederick.racke@osumc.edu
 
     

Nilsa C Ramirez, M.D.

Cl Assoc Professor
Pathology
Research II Building 5th Floor
700 Children's Dr. Columbus,OH. 43205

 

o

(614) 722-5643

f

(614) 722-5895
nilsa.ramirez@nationwidechildrens.org
 
     

Wolfgang Sadee, Ph.D.

Professor
Pharmacology
5072 Graves Hall
333 West 10th Avenue Columbus,OH. 43210

 

o

(614) 292-1597

f

(614) 292-7232
wolfgang.sadee@osumc.edu
 
     

Larry J. Schaaf, Ph.D.

Adj Professor
Pharmacy
1232 James Cancer Hospital
300 West 10th Avenue Columbus,OH. 43210

 

o

(614) 293-6307

f

(614) 293-4072
larry.schaaf@osumc.edu
 
     

Thomas D. Schmittgen, Ph.D.

Assoc Professor
Pharmacy
536 Parks Hall
500 W.12th Ave. Columbus,OH. 43210

 

o

(614) 292-3456

f

(614) 292-7766
schmittgen.2@osu.edu
 
     

Manisha H. Shah, M.D.

Assoc Professor
Internal Medicine
A438 Starling Loving
320 W. 10th Avenue Columbus,OH. 43210

 

o

(614) 293-8629

f

(614) 293-3112
manisha.shah@osumc.edu
 
     

Said Sif, M.Sc., Ph.D.

Assoc Professor
Molecular and Cellular Biochemistry
468 Hamilton Hall
1645 Neil Avenue Columbus,OH. 43210

 

o

(614) 247-7445

f

(614) 292-4118
sif.1@osu.edu
 
     

Theodoros N Teknos, M.D.

Professor
Otolaryngology
300 Cramblett Hall
456 W 10th Ave. Columbus,OH. 43210

 

o

(614) 293-8074

f

ted.teknos@osumc.edu
 
     

Amanda M Termuhlen, M.D.

Professor-Clinical
Pediatrics
Columbus Children's Hospital
700 Children's Drive Columbus,OH. 43205

 

o

(614) 722-3552

f

(614) 722-3699
Amanda.Termuhlen@nationwidechildrens.org
 
     

James P. Thomas, M.D., Ph.D.

Assoc Professor
Internal Medicine
6-016 Batelle
1375 Perry Street Columbus,OH. 43201

 

o

(614) 293-8569

f

james.thomas@osumc.edu
 
     

Werner Tjarks, Ph.D.

Assoc Professor
Pharmacy
421 Parks Hall
500 W. 12th Avenue Columbus,OH. 43210

 

o

(614) 292-7624

f

(614) 292-2435
tjarks.1@osu.edu
 
     

Michael F Tweedle, Ph.D.

Professor
Radiology
712 BRT
460 W 12th Ave Columbus,OH. 43210

 

o

(614) 247-4427

f

Michael.Tweedle@osumc.edu
 
     

Miguel A. Villalona, M.D., FACP

Professor
Internal Medicine
B406 Starling-Loving
320 W. 10th Avenue Columbus,OH. 43210

 

o

(614) 293-9424

f

(614) 293-4372
miguel.villalona@osumc.edu
 
     

Brian Weiss, M.D.

Research Asst Professor
Pediatrics
MLC R 7015
3333 Burnet Ave Cincinnati,OH. 452293039

 

o

(513) 636-4266

f

(513) 636-3549
Brian.Weiss@cchmc.org
 
     

Haifeng M Wu, M.D.

Assoc Professor
Pathology
185A Hamilton Hall
1645 Neil Ave Columbus,OH. 43210

 

o

(614) 292-9335

f

(614) 292-3144
haifeng.wu@osumc.edu