NCI CCC
The Ohio State University Comprehensive Cancer Center
Home :
Research Programs


 

 

 

 

 

Research Programs


Molecular Biology and Cancer Genetics

Researchers in this program strive to better understand the association between genes and cancer and to exploit this association to reduce the incidence of cancer death. Specific aims are to: 1) identify human genes that, either through direct mutations or epigenetic mechanisms, predispose individuals to cancer; 2) determine molecular mechanisms underlying the expression and function of genes contributing to normal development and multi-stage cancer progression (studies in model organisms are critical to this aim); and 3) promote clinical applications of gene identification and an understanding of their functions for better diagnosis, prognosis, surveillance, prevention and treatment of cancer. Studies use common analytical tools in biochemistry, cell biology, genetics, recombinant DNA technology and transgenic organisms. The clinical component of this program is integrated with the basic molecular and translational studies, moving research from lab bench to bedside and back to bench.

A major initiative in the MBCG Program is the Program Project Grant (PPG), a $8.7 million grant from the National Cancer Institute to investigate Genetic Analysis of the Tumor Microenvironment. Read more about the Program Project Grant.

Program Leaders

     

Albert de la Chapelle, M.D., Ph.D.

Professor
Molecular Virology, Immunology & Medical Genetics
804 Biomedical Res. Tower
460 W. 12th Avenue Columbus,OH. 43210

 

o

(614) 688-4781

f

(614) 688-4763
albert.delachapelle@osumc.edu
 
     

Michael C. Ostrowski, Ph.D.

Professor / Chair
Molecular and Cellular Biochemistry
810 Biomedical Research Tower
460 West 12th Avenue Columbus,OH. 43210

 

o

(614) 688-3824

f

(614) 688-8727
michael.ostrowski@osumc.edu
 

Program Members

     

Mohamed H Abdel-Rahman, M.D., Ph.D.

Asst Professor
Ophthalmology
252N Wiseman Hall
400 W 12th Ave Columbus,OH. 43221

 

o

(614) 293-3159

f

(614) 247-7153
mohamed.abdel-rahman@osumc.edu
 
     

Carlos E Alvarez, Ph.D.

Asst. Professor
Pediatrics
Nationwide Children's Hospital
700 Children's Dr. Columbus,OH. 43205

 

o

(614) 355-3600

f

(614) 722-2817
Alvarez.73@osu.edu
 
     

Rami I Aqeilan, Ph.D.

Research Asst Professor
Molecular Virology, Immunology & Medical Genetics
435 Wiseman Hall
400 West 12th Columbus,OH. 43210

 

o

(614) 292-3120

f

(614) 292-3312
rami.aqeilan@osumc.edu
 
     

Bruce Aronow, Ph.D.

Professor
Pediatrics
S.10.248
240 Albert Sabin Way Cincinnati,OH. 45229

 

o

(513) 636-4865

f

(513) 636-2056
bruce.aronow@cchmc.org
 
     

Maki Asano, Ph.D.

Asst Professor
Molecular and Cellular Biochemistry
812 Biomed TWR
460 W 12th Ave Columbus,OH. 43210

 

o

(614) 688-4164

f

maki.asano@osumc.edu
 
     

John A Barnard, M.D.

Professor
Pediatrics
Children's Hospital, Room W502
700 Children's Drive Columbus,OH. 43205

 

o

(614) 722-3450

f

(614) 722-3273
John.Barnard@nationwidechildrens.org
 
     

Clara D Bloomfield, M.D.

Professor
Internal Medicine
519C James
300 West 10th Avenue Columbus,OH. 43210

 

o

(614) 293-7518

f

(614) 293-3132
clara.bloomfield@osumc.edu
 
     

Mark Bloomston, M.D.

Asst Professor
Surgery
N924 Doan Hall
410 W 10th Avenue Columbus,OH. 43210

 

o

(614) 293-4583

f

(614) 293-3465
Mark.Bloomston@osumc.edu
 
     

Kristie Blum, M.D.

Asst Professor
Internal Medicine
A441 Starling Loving
320 W. 10th Avenue Columbus,OH. 43210

 

o

(614) 293-3507

f

(614) 293-7484
kristie.blum@osumc.edu
 
     

William G Blum, M.D.

Asst Professor
Internal Medicine
B312 Starling Loving Hall
320 W. 10th Avenue Columbus,OH. 43210

 

o

(614) 293-9210

f

william.blum@osumc.edu
 
     

Michael A. Caligiuri, M.D.

Professor
Internal Medicine/ OSUCCC
521B James Cancer Hospital
300 W. 10th Avenue Columbus,OH. 43210

 

o

(614) 293-7521

f

(614) 293-3122
michael.caligiuri@osumc.edu

 

Other Programs:

Innate Immunity
Administrative
     

Dawn S. Chandler, Ph.D.

Asst Professor
Pediatrics
Columbus Children's Research Institute
700 Children's Drive WA5023 Columbus,OH. 43205

 

o

(614) 722-5598

f

(614) 722-5895
Dawn.Chandler@nationwidechildrens.org
 
     

Susan E Cole, Ph.D.

Asst Professor
Molecular Genetics
984 Biological Sciences Bldg
484 W 12th Ave Columbus,OH. 43210

 

o

(614) 292-3276

f

(614) 292-4466
cole.354@osu.edu
 
     

Carlo M Croce, M.D.

Professor/ Chair
Molecular Virology, Immunology & Medical Genetics
455d Comprehensive Cancer Center
400 W. 12th Ave. Columbus,OH. 43210

 

o

(614) 292-4930

f

(614) 292-4080
carlo.croce@osumc.edu
 
     

Heithem M El-hodiri, Ph.D.

Assoc Professor
Pediatrics
Children's Research Institute
700 Children's Drive Columbus,OH. 43205

 

o

(614) 722-2868

f

(614) 722-2817
Heithem.El-Hodiri@nationwidechildrens.org
 
     

Richard Fishel, Ph.D.

Professor
Molecular Virology, Immunology & Medical Genetics
385N Comprehensive Cancer Center
400 w 12th Ave Columbus,OH. 43210

 

o

(614) 292-2584

f

(614) 688-4994
richard.fishel@osumc.edu
 
     

Harold A Fisk, Ph.D.

Asst Professor
Molecular Genetics/ Biological Sciences
272 Bioscience
484 W. 12th Ave Columbus,OH. 43210

 

o

(614) 292-0318

f

(614) 292-4466
fisk.13@osu.edu
 
     

Ramesh K Ganju, Ph.D.

Professor
Pathology
185D Hamilton Hall
1645 Neil Ave. Columbus,OH. 43210

 

o

(614) 292-5539

f

(614) 247-0051
ramesh.ganju@osumc.edu
 
     

Ramiro Garzon, M.D.

Asst Professor
Internal Medicine
1084 Biomedical Research Tower
460 W. 12th Ave. Columbus,OH. 43210

 

o

(614) 293-9868

f

(614) 292-4097
Ramiro.Garzon@osumc.edu
 
     

Joanna L Groden, Ph.D.

Professor
Molecular Virology, Immunology & Medical Genetics
BRT 986
460 W. 12th Avenue Columbus,OH. 43210

 

o

(614) 688-4301

f

(614) 292-4080
joanna.groden@osumc.edu
 
     

Metin N Gurcan, Ph.D.

Asst Professor
Biomedical Informatics
3190 Graves Hall
333 W 10th Ave Columbus,OH. 43210

 

o

(614) 292-1084

f

Metin.Gurcan@osumc.edu
 
     

Denis C Guttridge, Ph.D.

Assoc Professor
Molecular Virology, Immunology & Medical Genetics
554 Tzagournis Medical Research Facility
420 W. 12th Avenue Columbus,OH. 43210

 

o

(614) 688-3137

f

(614) 247-6842
denis.guttridge@osumc.edu
 
     

Tsonwin Hai, Ph.D.

Professor
Molecular and Cellular Biochemistry
174 Rightmire Hall
1060 Carmack Road Columbus,OH. 43210

 

o

(614) 292-2910

f

(614) 292-5379
hai.2@osu.edu
 
     

Gail E. Herman, M.D., Ph.D.

Professor
Pediatrics
Children's Hospital Research Foundation
700 Children's Drive Columbus,OH. 432052696

 

o

(614) 722-2848

f

(614) 722-2716
Gail.Herman@nationwidechildrens.org
 
     

Paul K Herman, Ph.D.

Assoc Professor
Molecular Genetics
984 Biological Sciences Builiding
484 W 12 Ave. Columbus,OH. 43210

 

o

(614) 688-5581

f

(614) 292-4466
herman.81@osu.edu
 
     

Tim Hui-ming Huang, Ph.D.

Professor
Molecular Virology, Immunology & Medical Genetics
814 Biomedical Research Tower
460 W. 12th Avenue Columbus,OH. 43210

 

o

(614) 688-8277

f

(614) 688-3981
tim.huang@osumc.edu
 
     

F Kay Huebner, Ph.D.

Professor
Molecular Virology, Immunology & Medical Genetics
916 Biomedical Research Tower
460 W. 12th Ave. Columbus,OH. 43210

 

o

(614) 292-4850

f

(614) 292-3312
kay.huebner@osumc.edu
 
     

Sissy M. Jhiang, Ph.D.

Professor
Physiology and Cell Biology
302 Hamilton Hall
1645 Neil Avenue Columbus,OH. 43210

 

o

(614) 292-4312

f

(614) 292-4888
jhiang.1@osu.edu
 
     

Victor X Jin, Ph.D.

Assistant Prof
Biomedical Informatics
3172C Graves Hall
333 W 10th Ave Columbus,OH. 43210

 

o

(614) 292-6931

f

(314) 688-6600
Victor.Jin@osumc.edu
 
     

Lawrence S Kirschner, M.D., Ph.D.

Assoc Professor
Internal Medicine
544 Tzagournis Medical Research Facility
420 W. 12th Street Columbus,OH. 43210

 

o

(614) 292-1190

f

(614) 247-6842
lawrence.kirschner@osumc.edu
 
     

Chang-hyuk Kwon, Ph.D.

Asst. Professor
Neurological Surgery
820 BRT
460 W 12th Ave Columbus,OH. 43210

 

o

(614) 688-5867

f

chang-hyuk.kwon@osumc.edu
 
     

Gustavo W. Leone, Ph.D.

Assoc Professor
Molecular Virology, Immunology & Medical Genetics
808 Biomedical Research Tower
460 W. 12th Avenue Columbus,OH. 43210

 

o

(614) 688-4567

f

(614) 688-4245
gustavo.leone@osumc.edu
 
     

Nancy L Lill, Ph.D.

Assoc Professor
Pathology
139 Hamilton Hall
1645 Neil Ave Columbus,OH. 43210

 

o

(614) 247-8051

f

(614) 293-2779
Nancy.Lill@osumc.edu
 
     

Huey-jen Lin, Ph.D.

Asst Professor
School of Allied Medical Professions/Medical Dietetics Division
535 Atwell Hall
453 W. 10th St. Columbus,OH. 43210

 

o

(614) 292-7303

f

lin.661@osu.edu
 
     

Jun Liu, Ph.D.

Asst Professor
Biomedical Engineering Center
270 Bevis Hall Columbus,OH. 43210

 

o

(614) 247-8904

f

(614) 292-7301
liu.314@osu.edu
 
     

Cheryl London, D.V.M.

Assoc Professor
Veterinary Biosciences
Vet Med Academic Bldg
1900 Coffey Road Columbus,OH. 43210

 

o

(614) 292-9554

f

(614) 292-7599
london.20@osu.edu
 
     

Kirk M Mchugh, Ph.D.

Assoc Professor
Pediatrics
W432
700 Children's Drive Columbus,OH. 43210

 

o

(614) 722-3273

f

(614) 722-3273
Kirk.McHugh@nationwidechildrens.org
 
     

James C Mulloy, Ph.D.

Asst Professor
Pediatrics
S7.603/ML 7013
3333 Burnet Ave Cincinnati,OH. 45229

 

o

(513) 636-1844

f

(513) 636-3768
james.Mulloy@cchmc.org
 
     

Patrick Nana-Sinkam, M.D.

Asst Professor
Internal Medicine
201 DHLRI
473 W. 12th Ave Columbus,OH. 43210

 

o

(614) 247-7707

f

Patrick.Nana-Sinkam@osumc.edu
 
     

Gerard J. Nuovo, M.D.

Professor
Pathology
081 Heart and Lung Research Institute
473 W.12th Ave Columbus,OH. 43210

 

o

(614) 247-4398

f

(614) 247-7490
Gerard.Nuovo@osumc.edu
 
     

Stephen A Osmani, Ph.D.

Professor
Molecular Genetics
804 Riffe Building
496 W. 12th Avenue Columbus,OH. 43210

 

o

(614) 247-6791

f

(614) 247-6845
osmani.2@osu.edu
 
     

Gregory A. Otterson, M.D.

Assoc Professor
Internal Medicine
B415 Starling Loving
320 W. 10th Avenue Columbus,OH. 43210

 

o

(614) 293-2887

f

(614) 293-4372
greg.otterson@osumc.edu
 
     

Hay-Oak Park, Ph.D.

Assoc Professor
Molecular Genetics
984 Bioscience Building
484 West 12th Avenue Columbus,OH. 43210

 

o

(614) 688-4575

f

(614) 292-4466
park.294@osu.edu
 
     

Jeffrey Parvin, M.D., Ph.D.

Professor
Biomedical Informatics
Room 904
460 W. 12th Avenue Columbus,OH. 43210

 

o

(614) 293-0523

f

jeffrey.parvin@osumc.edu
 
     

Danilo Perrotti, M.D., Ph.D.

Assoc Professor
Molecular Virology, Immunology & Medical Genetics
440 Tzagournis Medical Research Facility
420 W. 12th Avenue Columbus,OH. 43210

 

o

(614) 292-4158

f

(614) 688-4761
danilo.perrotti@osumc.edu
 
     

Joseph J Pinzone, M.D., M.B.A.

Asst Professor
Internal Medicine
McCampbell Hall, Rm 445C
1581 Dodd Drive Columbus,OH. 43210

 

o

(614) 292-4396

f

(614) 292-1550
joseph.pinzone@osumc.edu
 
     

Nancy Ratner, Ph.D.

Professor
Pediatrics
Room R-2325, MLC 7013
3333 Burnet Ave Cincinnati,OH. 452293039

 

o

(513) 636-9469

f

(513) 636-3549
nancy.ratner@cchmc.org
 
     

Matthew D Ringel, M.D.

Professor
Internal Medicine
1249 James
300 W. 10th Ave. Columbus,OH. 43210

 

o

(614) 292-4356

f

(614) 292-1550
matthew.ringel@osumc.edu
 
     

Daniel R. Schoenberg, Ph.D.

Professor
Molecular and Cellular Biochemistry
366 Hamilton
1645 Neil Ave Columbus,OH. 43210

 

o

(614) 688-3012

f

(614) 292-4118
Schoenberg.3@osu.edu
 
     

Amanda A. Simcox, Ph.D.

Professor
Molecular Genetics
963 Bioscience
484 W. 12th Avenue Columbus,OH. 43210

 

o

(614) 292-8857

f

(614) 292-4466
simcox.1@osu.edu
 
     

Amanda E Toland, Ph.D.

Asst Professor
Molecular Virology, Immunology & Medical Genetics
998 BRT
460 W. 12th Ave Columbus,OH. 43210

 

o

(614) 247-8185

f

(614) 688-8675
amanda.toland@osumc.edu
 
     

Sung Ok Yoon, Ph.D.

Assoc Professor
Molecular and Cellular Biochemistry
060 Rightmire Hall
1060 Carmack Road Columbus,OH. 43210

 

o

(614) 292-8542

f

(614) 292-5379
yoon.84@osu.edu