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OSUCCC
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Carlo M Croce, M.D.
Director of HCG Director / Principal Investigator
Professor/ Chair
College of Medicine
Molecular Virology, Immunology & Medical Genetics - Human Cancer Genetics
455d Comprehensive Cancer Center
400 W. 12th Ave. Columbus,OH. 43210
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(614) 292-4930 |
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(614) 292-4080 |
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Programs
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Current Publications
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Nat Rev Cancer 6(11): 857-66, 3--6
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MicroRNA signatures in human cancers.
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Calin GA, Croce CM
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Nat Protoc 4(1): 107-15, 2009
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A methodology for the combined in situ analyses of the precursor and mature forms of microRNAs and correlation with their putative targets.
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Nuovo GJ, Elton TS, Nana-Sinkam P, Volinia S, Croce CM, Schmittgen TD
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Blood 113(22): 5568-74, 2009
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Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells.
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Ghosh AK, Shanafelt TD, Cimmino A, Taccioli C, Volinia S, Liu CG, Calin GA, Croce CM, Chan DA, Giaccia AJ, Secreto C, Wellik LE, Lee YK, Mukhopadhyay D, Kay NE
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Int J Oncol 35(2): 393-400, 2009
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Altered expression of selected microRNAs in melanoma: antiproliferative and proapoptotic activity of miRNA-155.
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Levati L, Alvino E, Pagani E, Arcelli D, Caporaso P, Bondanza S, Di Leva G, Ferracin M, Volinia S, Bonmassar E, Croce CM, D'Atri S
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Cancer Res 69(21): 8249-55, 2009
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Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network.
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Zaidi SK, Dowdy CR, van Wijnen AJ, Lian JB, Raza A, Stein JL, Croce CM, Stein GS
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PLoS One 4(2): e4352, 2009
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At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1.
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Hagan JP, O'Neill BL, Stewart CL, Kozlov SV, Croce CM
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J Biol Chem 284(23): 15676-84, 2009
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Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation.
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Li Z, Hassan MQ, Jafferji M, Garzon R, Croce CM, van Wijnen AJ, Stein JL, Stein GS, Lian JB
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Ann Surg Oncol 16(8): 2331-8, 2009
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Coordinate loss of fragile gene expression in pancreatobiliary cancers: correlations among markers and clinical features.
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Bloomston M, Kneile J, Butterfield M, Dillhoff M, Muscarella P, Ellison EC, Melvin WS, Croce CM, Pichiorri F, Huebner K, Frankel WL
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J Biol Chem 284(2): 1040-9, 2009
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Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions.
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Pichiorri F, Okumura H, Nakamura T, Garrison PN, Gasparini P, Suh SS, Druck T, McCorkell KA, Barnes LD, Croce CM, Huebner F
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Proc Natl Acad Sci U S A 106(15): 6250-5, 2009
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E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction.
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Gorgun G, Ramsay AG, Holderried TA, Zahrieh D, Le Dieu R, Liu F, Quackenbush J, Croce CM, Gribben JG
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Proc Natl Acad Sci U S A 106(32): 13433-8, 2009
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Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia.
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Chen SS, Raval A, Johnson AJ, Hertlein E, Liu TH, Jin VX, Sherman MH, Liu SJ, Dawson DW, Williams KE, Lanasa M, Liyanarachchi S, Lin TS, Marcucci G, Pekarsky Y, Davuluri R, Croce CM, Guttridge DC, Teitell MA, Byrd JC, Plass C
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Hepatology 50(2): 472-80, 2009
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Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells.
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Ji J, Yamashita T, Budhu A, Forgues M, Jia HL, Li C, Deng C, Wauthier E, Reid LM, Ye QH, Qin LX, Yang W, Wang HY, Tang ZY, Croce CM, Wang XW
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Cell Stem Cell 5(1): 111-23, 2009
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Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures.
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Chin MH, Mason MJ, Xie W, Volinia S, Singer M, Peterson C, Ambartsumyan G, Aimiuwu O, Richter L, Zhang J, Khvorostov I, Ott V, Grunstein M, Lavon N, Benvenisty N, Croce CM, Clark AT, Baxter T, Pyle AD, Teitell MA, Pelegrini M, Plath K, Lowry WE
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in press: , 2009
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Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia.
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Sanchez-Aguilera A, Rattmann I, Drew DZ, Müller LU, Summey V, Lucas DM, Byrd JC, Croce CM, Gu Y, Cancelas JA, Johnston P, Moritz T, Williams DA
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Blood 114(18): 3872-9, 2009
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Karyotype-specific microRNA signature in chronic lymphocytic leukemia.
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Visone R, Rassenti LZ, Veronese A, Taccioli C, Costinean S, Aguda BD, Volinia S, Ferracin M, Palatini J, Balatti V, Alder H, Negrini M, Kipps TJ, Croce CM
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in press: , 2009
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MicroRNA 29b functions in acute myeloid leukemia.
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Garzon R, Heaphy CE, Havelange V, Fabbri M, Volinia S, Tsao T, Zanesi N, Kornblau SM, Marcucci G, Calin GA, Andreeff M, Croce CM
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Clin Cancer Res 15(19): 6192-200, 2009
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MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: associations with survival.
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Mathé EA, Nguyen GH, Bowman ED, Zhao Y, Budhu A, Schetter AJ, Braun R, Reimers M, Kumamoto K, Hughes D, Altorki NK, Casson AG, Liu CG, Wang XW, Yanaihara N, Hagiwara N, Dannenberg AJ, Miyashita M, Croce CM, Harris CC
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Best Pract Res Clin Haematol 22(2): 239-48, 2009
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MicroRNA expression profiling in acute myeloid and chronic lymphocytic leukaemias.
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Marcucci G, Mrózek K, Radmacher MD, Bloomfield CD, Croce CM
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J Pathol 219(2): 214-21, 2009
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MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets.
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Baffa R, Fassan M, Volinia S, O'Hara B, Liu CG, Palazzo JP, Gardiman M, Rugge M, Gomella LG, Croce CM, Rosenberg A
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Breast Cancer Res 11(4): R58, 2009
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MicroRNA expression profiling of male breast cancer.
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Fassan M, Baffa R, Palazzo JP, Lloyd J, Crosariol M, Liu CG, Volinia S, Alder H, Rugge M, Croce CM, Rosenberg A
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N Engl J Med 361(15): 1437-47, 2009
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MicroRNA expression, survival, and response to interferon in liver cancer.
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Ji J, Shi J, Budhu A, Yu Z, Forgues M, Roessler S, Ambs S, Chen Y, Meltzer PS, Croce CM, Qin LX, Man K, Lo CM, Lee J, Ng IO, Fan J, Tang ZY, Sun HC, Wang XW
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Cancer Res 69(6): 2195-200, 2009
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microRNA-205 regulates HER3 in human breast cancer.
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Iorio MV, Casalini P, Piovan C, Di Leva G, Merlo A, Triulzi T, Ménard S, Croce CM, Tagliabue E
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Clin Cancer Res 15(16): 5073-81, 2009
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MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality.
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Gramantieri L, Fornari F, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Croce CM, Bolondi L, Negrini M
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Blood 113(25): 6411-8, 2009
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MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.
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Garzon R, Liu S, Fabbri M, Liu Z, Heaphy CE, Callegari E, Schwind S, Pang J, Yu J, Muthusamy N, Havelange V, Volinia S, Blum W, Rush LJ, Perrotti D, Andreeff M, Bloomfield CD, Byrd JC, Chan K, Wu LC, Croce CM, Marcucci G
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Cell Death Differ in press: , 2009
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MicroRNAs as regulators of death receptors signaling.
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Garofalo M, Condorelli GL, Croce CM, Condorelli G
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Annu Rev Med 60: 167-79, 2009
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MicroRNAs in Cancer.
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Garzon R, Calin GA, Croce CM
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in press: , 2009
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MicroRNAs in Cancer: Small Molecules With a Huge Impact.
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Iorio MV, Croce CM
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Leuk Lymphoma 50(2): 160-70, 2009
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MicroRNAs in the ontogeny of leukemias and lymphomas.
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Fabbri M, Croce CM, Calin GA
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Br J Cancer 101(5): 743-8, 2009
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MicroRNAs: new players in acute myeloid leukaemia.
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Havelange V, Garzon R, Croce CM
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Cancer Res 69(14): 5761-7, 2009
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MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells.
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Fornari F, Gramantieri L, Giovannini C, Veronese A, Ferracin M, Sabbioni S, Calin GA, Grazi GL, Croce CM, Tavolari S, Chieco P, Negrini M, Bolondi L
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Int Rev Immunol 28(5): 264-84, 2009
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miR-155: on the crosstalk between inflammation and cancer.
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Tili E, Croce CM, Michaille JJ
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Cell Death Differ in press: , 2009
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miR-15a and miR-16-1 in cancer: discovery, function and future perspectives.
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Aqeilan RI, Calin GA, Croce CM
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Proc Natl Acad Sci U S A 106(29): 12085-90, 2009
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MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers.
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Seike M, Goto A, Okano T, Bowman ED, Schetter AJ, Horikawa I, Mathe EA, Jen J, Yang P, Sugimura H, Gemma A, Kudoh S, Croce CM, Harris CC
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Am J Pathol 174(4): 1131-8, 2009
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MiRNAs and cancer.
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Visone R, Croce CM
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J Natl Compr Canc Netw 7 Suppl 4: S1-34, quiz S35-6, 2009
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NCCN task force report: molecular markers in leukemias and lymphomas.
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Radich JP, Zelenetz AD, Chan WC, Croce CM, Czuczman MS, Erba HP, Horning SJ, Houldsworth J, Smith BD, Snyder DS, Sundar HM, Wetzler M, Winter JN
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Cancer Genomics Proteomics 6(4): 195-204, 2009
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Pathogenetic and clinical relevance of MicroRNAs in colorectal cancer.
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Valeri N, Croce CM, Fabbri M
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Urol Oncol in press: , 2009
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Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor.
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D'Arca D, Lenoir J, Wildemore B, Gottardo F, Bragantini E, Shupp-Byrne D, Zanesi N, Fassan M, Croce CM, Gomella LG, Baffa R
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Oncogene 28(11): 1432-42, 2009
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Regulation of microRNA expression by HMGA1 proteins.
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De Martino I, Visone R, Fedele M, Petrocca F, Palmieri D, Martinez Hoyos J, Forzati F, Croce CM, Fusco A
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Hepatology 50(4): 1152-61, 2009
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Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice.
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Wang B, Majumder S, Nuovo G, Kutay H, Volinia S, Patel T, Schmittgen TD, Croce C, Ghoshal K, Jacob ST
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Cell 137(3): 586-586.e1, 2009
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SnapShot: MicroRNAs in Cancer.
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Spizzo R, Nicoloso MS, Croce CM, Calin GA
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Blood 114(7): 1374-82, 2009
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Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice.
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Costinean S, Sandhu SK, Pedersen IM, Tili E, Trotta R, Perrotti D, Ciarlariello D, Neviani P, Harb J, Kauffman LR, Shidham A, Croce CM
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DNA Cell Biol 28(4): 161-7, 2009
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Targeted disruption of the murine homeodomain-interacting protein kinase-2 causes growth deficiency in vivo and cell cycle arrest in vitro.
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Trapasso F, Aqeilan RI, Iuliano R, Visone R, Gaudio E, Ciuffini L, Alder H, Paduano F, Pierantoni GM, Soddu S, Croce CM, Fusco A
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Cancer Res 69(8): 3249-55, 2009
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The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors.
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Northcott PA, Fernandez-L A, Hagan JP, Ellison DW, Grajkowska W, Gillespie Y, Grundy R, Van Meter T, Rutka JT, Croce CM, Kenney AM, Taylor MD
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Oncogene 28(10): 1329-38, 2009
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The Tcl1 oncogene defines secondary hair germ cells differentiation at catagen-telogen transition and affects stem-cell marker CD34 expression.
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Ragone G, Bresin A, Piermarini F, Lazzeri C, Picchio MC, Remotti D, Kang SM, Cooper MD, Croce CM, Narducci MG, Russo G
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J Biol Chem 284(40): 27487-99, 2009
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Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks.
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Naga Prasad SV, Duan ZH, Gupta MK, Surampudi VS, Volinia S, Calin GA, Kotwal A, Moravec CS, Starling RC, Perez DM, Sen S, Wu Q, Plow EF, Croce CM, Karnik S
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Proc Natl Acad Sci U S A 105(36): 13556-61, 2008
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A microRNA DNA methylation signature for human cancer metastasis.
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Lujambio A, Calin GA, Villanueva A, Ropero S, Sánchez-Céspedes M, Blanco D, Montuenga LM, Rossi S, Nicoloso MS, Faller WJ, Gallagher WM, Eccles SA, Croce CM, Esteller M
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Proc Natl Acad Sci U S A 105(37): 13906-11, 2008
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A microRNA signature for a BMP2-induced osteoblast lineage commitment program.
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Li Z, Hassan MQ, Volinia S, van Wijnen AJ, Stein JL, Croce CM, Lian JB, Stein GS
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Genes Dev 22(24): 3403-8, 2008
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Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
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Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
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Proc Natl Acad Sci U S A 104(36): 14442-7, 2008
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ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias.
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Nakanishi H, Nakamura T, Canaani E, Croce CM
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Cancer Res 67(19): 9330-6, 2008
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Association of Wwox with ErbB4 in breast cancer.
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Aqeilan RI, Donati V, Gaudio E, Nicoloso MS, Sundvall M, Korhonen A, Lundin J, Isola J, Sudol M, Joensuu H, Croce CM, Elenius K
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Clin Cancer Res 14(21): 6797-803, 2008
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BRCA1 5083del19 mutant allele selectively up-regulates periostin expression in vitro and in vivo.
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Quaresima B, Romeo F, Faniello MC, Di Sanzo M, Liu CG, Lavecchia A, Taccioli C, Gaudio E, Baudi F, Trapasso F, Croce CM, Cuda G, Costanzo F
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BMC Biotechnol 7: 82, 2008
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Compatible solutes from hyperthermophiles improve the quality of DNA microarrays.
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Mascellani N, Liu X, Rossi S, Marchesini J, Valentini D, Arcelli D, Taccioli C, Helmer Citterich M, Liu CG, Evangelisti R, Russo G, Santos JM, Croce CM, Volinia S
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Pituitary 11(2): 121-8, 2008
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Diagnosis of adult GH deficiency.
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Gasco V, Corneli G, Rovere S, Croce CM, Beccuti G, Mainolfi A, Grottoli S, Aimaretti G, Ghigo E
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Proc Natl Acad Sci U S A 105(10): 3945-50, 2008
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Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin.
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Garzon R, Garofalo M, Martelli MP, Briesewitz R, Wang L, Fernandez-Cymering C, Volinia S, Liu CG, Schnittger S, Haferlach T, Liso A, Diverio D, Mancini M, Meloni G, Foa R, Martelli MF, Mecucci C, Croce CM, Falini B
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FASEB J 23(3): 806-12, 2008
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Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke.
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Izzotti A, Calin GA, Arrigo P, Steele VE, Croce CM, De Flora S
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Cancer Cell 13(3): 272-86, 2008
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E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer.
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Petrocca F, Visone R, Onelli MR, Shah MH, Nicoloso MS, de M, Iliopoulos D, Pilozzi E, Liu CG, Negrini M, Cavazzini L, Volinia S, Alder H, Ruco LP, Baldassarre G, Croce CM, Vecchione A
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Cancer Res 68(20): 8191-4, 2008
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Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling.
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Petrocca F, Vecchione A, Croce CM
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J Virol 82(21): 10436-43, 2008
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Epstein-Barr virus-induced miR-155 attenuates NF-kappaB signaling and stabilizes latent virus persistence.
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Lu F, Weidmer A, Liu CG, Volinia S, Croce CM, Lieberman PM
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Prostate 68(11): 1152-64, 2008
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Expression of microRNAs and protein-coding genes associated with perineural invasion in prostate cancer.
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Prueitt RL, Yi M, Hudson RS, Wallace TA, Howe TM, Yfantis HG, Lee DH, Stephens RM, Liu CG, Calin GA, Croce CM, Ambs S
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Methods 44(1): 22-30, 2008
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Expression profiling of microRNA using oligo DNA arrays.
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Liu CG, Spizzo R, Calin GA, Croce CM
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Carcinogenesis 29(4): 846-8, 2008
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Fez1/Lzts1-deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesis.
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Baffa R, Fassan M, Sevignani C, Vecchione A, Ishii H, Giarnieri E, Iozzo RV, Gomella LG, Croce CM
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J Biol Chem 283(20): 13736-44, 2008
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Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.
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Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Di LG, Fabbri M, Birk DE, Raso C, Green-Church K, Spagnoli LG, Venuta S, Huebner K, Croce CM
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Cancer Cell 13(6): 496-506, 2008
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Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression.
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Bueno MJ, Perez dC, Gomez de CM, Santos J, Calin GA, Cigudosa JC, Croce CM, Fernandez-Piqueras J, Malumbres M
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PLoS One 3(10): e3380, 2008
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Genome wide identification of recessive cancer genes by combinatorial mutation analysis.
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Volinia S, Mascellani N, Marchesini J, Veronese A, Ormondroyd E, Alder H, Palatini J, Negrini M, Croce CM
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Proc Natl Acad Sci U S A 105(19): 7004-9, 2008
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Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer.
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Zhang L, Volinia S, Bonome T, Calin GA, Greshock J, Yang N, Liu CG, Giannakakis A, Alexiou P, Hasegawa K, Johnstone CN, Megraw MS, Adams S, Lassus H, Huang J, Kaur S, Liang S, Sethupathy P, Leminen A, Simossis VA, Sandaltzopoulos R, Naomoto Y, Katsaros D, Gimotty PA, DeMichele A, Huang Q, Bützow R, Rustgi AK, Weber BL, Birrer MJ, Hatzigeorgiou AG, Croce CM, Coukos G
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Cancer Res 68(15): 6162-70, 2008
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Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer.
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Ambs S, Prueitt RL, Yi M, Hudson RS, Howe TM, Petrocca F, Wallace TA, Liu CG, Volinia S, Calin GA, Yfantis HG, Stephens RM, Croce CM
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Eur J Cancer 44(2): 318-25, 2008
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Hmga1 null mice are less susceptible to chemically induced skin carcinogenesis.
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Visone R, Iuliano R, Palmieri D, Server IN, Chiappetta G, De M, Fedele M, Costinean S, Oberyszyn TM, Kusewitt DF, Croce CM, Fusco A
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Eur J Cancer 44(17): 2668-79, 2008
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HMGA1 protein is a novel target of the ATM kinase.
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Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
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J Virol 82(18): 9065-74, 2008
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Human cytomegalovirus infection alters the expression of cellular microRNA species that affect its replication.
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Wang FZ, Weber F, Croce CM, Liu CG, Liao X, Pellett PE
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Hepatology 47(3): 897-907, 2008
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Identification of metastasis-related microRNAs in hepatocellular carcinoma.
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Budhu A, Jia HL, Forgues M, Liu CG, Goldstein D, Lam A, Zanetti KA, Ye QH, Qin LX, Croce CM, Tang ZY, Wang XW
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Cytogenet Genome Res 118(2-4): 196-203, 2008
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Influence of a nonfragile FHIT transgene on murine tumor susceptibility.
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McCorkell KA, Mancini R, Siprashvili Z, Barnoski BL, Iliopoulos D, Siracusa LD, Zanesi N, Croce CM, Fong LY, Druck T, Huebner K
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Nature 449(7164): 919-22, 2008
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Interferon modulation of cellular microRNAs as an antiviral mechanism.
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Pedersen IM, Cheng G, Wieland S, Volinia S, Croce CM, Chisari FV, David M
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Methods Enzymol 427: 193-213, 2008
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Investigation of microRNA alterations in leukemias and lymphomas.
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Calin GA, Croce CM
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Proc Natl Acad Sci U S A 105(11): 4162-7, 2008
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Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.
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Sundvall M, Korhonen A, Paatero I, Gaudio E, Melino G, Croce CM, Aqeilan RI, Elenius K
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Cell Cycle 7(17): 2643-6, 2008
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Mechanisms of microRNA deregulation in human cancer.
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Deng S, Calin GA, Croce CM, Coukos G, Zhang L
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Cancer Res 68(13): 5049-58, 2008
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Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.
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Datta J, Kutay H, Nasser MW, Nuovo GJ, Wang B, Majumder S, Liu CG, Volinia S, Croce CM, Schmittgen TD, Ghoshal K, Jacob ST
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N Engl J Med 358(18): 1919-28, 2008
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MicroRNA expression in cytogenetically normal acute myeloid leukemia.
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Marcucci G, Radmacher MD, Maharry K, Mrózek K, Ruppert AS, Paschka P, Vukosavljevic T, Whitman SP, Baldus CD, Langer C, Liu CG, Carroll AJ, Powell BL, Garzon R, Croce CM, Kolitz JE, Caligiuri MA, Larson RA, Bloomfield CD
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JAMA 299(4): 425-36, 2008
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MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma.
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Schetter AJ, Leung SY, Sohn JJ, Zanetti KA, Bowman ED, Yanaihara N, Yuen ST, Chan TL, Kwong DL, Au GK, Liu CG, Calin GA, Croce CM, Harris CC
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J Cell Mol Med 12(6A): 2189-204, 2008
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MicroRNA involvement in hepatocellular carcinoma.
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Gramantieri L, Fornari F, Callegari E, Sabbioni S, Lanza G, Croce CM, Bolondi L, Negrini M
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Cancer Res 68(24): 10307-14, 2008
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MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer.
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Yang N, Kaur S, Volinia S, Greshock J, Lassus H, Hasegawa K, Liang S, Leminen A, Deng S, Smith L, Johnstone CN, Chen XM, Liu CG, Huang Q, Katsaros D, Calin GA, Weber BL, Bützow R, Croce CM, Coukos G, Zhang L
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Eur J Cancer 44(18): 2753-9, 2008
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MicroRNA profiling as a tool to understand prognosis, therapy response and resistance in breast cancer.
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Iorio MV, Casalini P, Tagliabue E, Ménard S, Croce CM
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Urol Oncol 25(5): 387-92, 2008
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Micro-RNA profiling in kidney and bladder cancers.
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Gottardo F, Liu CG, Ferracin M, Calin GA, Fassan M, Bassi P, Sevignani C, Byrne D, Negrini M, Pagano F, Gomella LG, Croce CM, Baffa R
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Blood 111(6): 3183-9, 2008
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MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia.
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Garzon R, Volinia S, Liu CG, Fernandez-Cymering C, Palumbo T, Pichiorri F, Fabbri M, Coombes K, Alder H, Nakamura T, Flomenberg N, Marcucci G, Calin GA, Kornblau SM, Kantarjian H, Bloomfield CD, Andreeff M, Croce CM
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Oncogene 27(27): 3845-55, 2008
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MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer.
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Garofalo M, Quintavalle C, Di Leva G, Zanca C, Romano G, Taccioli C, Liu CG, Croce CM, Condorelli G
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J Gastrointest Surg 12(12): 2171-6, 2008
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MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival.
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Dillhoff M, Liu J, Frankel W, Croce C, Bloomston M
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Proc Natl Acad Sci U S A 104(40): 15805-10, 2008
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MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.
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Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E, Liu S, Alder H, Costinean S, Fernandez-Cymering C, Volinia S, Guler G, Morrison CD, Chan KK, Marcucci G, Calin GA, Huebner K, Croce CM
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Cancer Res 68(8): 2773-80, 2008
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MicroRNAs 221 and 222 bypass quiescence and compromise cell survival.
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Medina R, Zaidi SK, Liu CG, Stein JL, van Wijnen AJ, Croce CM, Stein GS
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Ann Oncol 19 Suppl 4: iv39-40, 2008
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MicroRNAs and lymphomas.
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Croce CM
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Cytogenet Genome Res 118(2-4): 252-9, 2008
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MicroRNAs in carcinogenesis.
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Hagan JP, Croce CM
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Curr Opin Pharmacol 8(5): 661-7, 2008
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MicroRNAs in diseases and drug response.
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Garofalo M, Condorelli G, Croce CM
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Gastroenterology 135(6): 1866-9, 2008
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Micro-RNAs in gastrointestinal and liver disease.
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Visone R, Petrocca F, Croce CM
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Curr Opin Hematol 15(4): 352-8, 2008
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MicroRNAs in normal and malignant hematopoiesis.
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Garzon R, Croce CM
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Br J Haematol 139(5): 709-16, 2008
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MicroRNAs in the pathogeny of chronic lymphocytic leukaemia.
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Nicoloso MS, Kipps TJ, Croce CM, Calin GA
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Mol Cancer Ther 7(1): 1-9, 2008
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MicroRNAs modulate the chemosensitivity of tumor cells.
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Blower PE, Chung JH, Verducci JS, Lin S, Park JK, Dai Z, Liu CG, Schmittgen TD, Reinhold WC, Croce CM, Weinstein JN, Sadee W
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Proc Natl Acad Sci U S A 105(35): 12885-90, 2008
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MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis.
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Pichiorri F, Suh SS, Ladetto M, Kuehl M, Palumbo T, Drandi D, Taccioli C, Zanesi N, Alder H, Hagan JP, Munker R, Volinia S, Boccadoro M, Garzon R, Palumbo A, Aqeilan RI, Croce CM
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Nat Clin Pract Rheumatol 4(10): 534-41, 2008
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MicroRNAs, the immune system and rheumatic disease.
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Tili E, Michaille JJ, Costinean S, Croce CM
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Cancer J 14(1): 1-6, 2008
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MicroRNAs.
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Fabbri M, Croce CM, Calin GA
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Proc Natl Acad Sci U S A 105(13): 5166-71, 2008
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MiR-15a and miR-16-1 cluster functions in human leukemia.
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Calin GA, Cimmino A, Fabbri M, Ferracin M, Wojcik SE, Shimizu M, Taccioli C, Zanesi N, Garzon R, Aqeilan RI, Alder H, Volinia S, Rassenti L, Liu X, Liu CG, Kipps TJ, Negrini M, Croce CM
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J Exp Med 205(10): 2199-206, 2008
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miR-181b negatively regulates activation-induced cytidine deaminase in B cells.
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de Yébenes VG, Belver L, Pisano DG, González S, Villasante A, Croce CM, He L, Ramiro AR
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Oncogene 27(43): 5651-61, 2008
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MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma.
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Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Giovannini C, Croce CM, Bolondi L, Negrini M
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Cancer Cell 14(5): 369-81, 2008
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NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma.
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Wang H, Garzon R, Sun H, Ladner KJ, Singh R, Dahlman J, Cheng A, Hall BM, Qualman SJ, Chandler DS, Croce CM, Guttridge DC
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N Engl J Med 358(5): 502-11, 2008
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Oncogenes and cancer.
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Croce CM
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Oncogene 26(54): 7590-5, 2008
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Specific microRNAs are downregulated in human thyroid anaplastic carcinomas.
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Visone R, Pallante P, Vecchione A, Cirombella R, Ferracin M, Ferraro A, Volinia S, Coluzzi S, Leone V, Borbone E, Liu CG, Petrocca F, Troncone G, Calin GA, Scarpa A, Colato C, Tallini G, Santoro M, Croce CM, Fusco A
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Mol Med 14(9-10): 618-27, 2008
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Surface expression of Bcl-2 in chronic lymphocytic leukemia and other B-cell leukemias and lymphomas without a breakpoint t(14;18).
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McCarthy BA, Boyle E, Wang XP, Guzowski D, Paul S, Catera R, Trott J, Yan XJ, Croce CM, Damle R, Yancopoulos S, Messmer BT, Lesser M, Allen SL, Rai KR, Chiorazzi N
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Cell Cycle 6(17): 2087-90, 2008
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Take your "M" time.
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Baldassarre G, Croce CM, Vecchione A
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Endocrinology 150(3): 1530-5, 2008
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Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis.
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Aqeilan RI, Hagan JP, de Bruin A, Rawahneh M, Salah Z, Gaudio E, Siddiqui H, Volinia S, Alder H, Lian JB, Stein GS, Croce CM
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Proc Natl Acad Sci U S A 105(50): 19643-8, 2008
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Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL.
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Pekarsky Y, Palamarchuk A, Maximov V, Efanov A, Nazaryan N, Santanam U, Rassenti L, Kipps T, Croce CM
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Cell Death Differ 15(2): 420-2, 2008
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TCL1 promotes blastomere proliferation through nuclear transfer, but not direct phosphorylation, of AKT/PKB in early mouse embryos.
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Fiorenza MT, Torcia S, Canterini S, Bevilacqua A, Marcucci G, Ragone G, Croce CM, Russo G, Mangia F
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Gynecol Oncol 112(1): 55-9, 2008
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The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform.
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Resnick KE, Alder H, Hagan JP, Richardson DL, Croce CM, Cohn DE
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J Biol Chem 283(31): 21629-39, 2008
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The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism.
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Aqeilan RI, Hassan MQ, de BA, Hagan JP, Volinia S, Palumbo T, Hussain S, Lee SH, Gaur T, Stein GS, Lian JB, Croce CM
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Nucleic Acids Res 37(Database issue): D41-8, 2008
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UCbase & miRfunc: a database of ultraconserved sequences and microRNA function.
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Taccioli C, Fabbri E, Visone R, Volinia S, Calin GA, Fong LY, Gambari R, Bottoni A, Acunzo M, Hagan J, Iorio MV, Piovan C, Romano G, Croce CM
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Am J Hum Genet 83(2): 180-92, 2008
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WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.
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Lee JC, Weissglas-Volkov D, Kyttälä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greevenbroek MM, Kane JP, Malloy MJ, Pullinger CR, Huertas-Vazquez A, Aguilar-Salinas CA, Tusie-Luna T, de Bruin TW, Aouizerat BE, van der Kallen CC, Croce CM, Aqeilan RI, Marcil M, Viikari JS, Lehtimäki T, Raitakari OT, Kuusisto J, Laakso M, Taskinen MR, Genest J, Pajukanta P
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Gastroenterology 136(3): 953-66, 2008
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Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat.
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Taccioli C, Wan SG, Liu CG, Alder H, Volinia S, Farber JL, Croce CM, Fong LY
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