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OSUCCC
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Said Sif, M.Sc., Ph.D.
Assoc Professor
College of Medicine
Molecular and Cellular Biochemistry
468 Hamilton Hall
1645 Neil Avenue Columbus,OH. 43210
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(614) 247-7445 |
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(614) 292-4118 |
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Programs
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The focus of research in my laboratory is to uncover how epigenetic modification of chromatin is altered in cancers such as mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL). More specifically, my group investigates how expression of protein arginine methyltransferases (PRMTs) is altered in cancer cells, and how this imbalance affects histone arginine methylation and impacts other epigenetic marks such as histone lysine methylation and DNA methylation. Research in my laboratory is also focused on understanding the mechanisms by which specific co-repressor and co-activators mediated by the multi-functional SWI/SNF complex serve to integrate transcriptional responses to distinct growth regulatory pathways. Specific target tumor suppressor genes are monitored both epigenetically as well as translationally to determine if various strategies, designed to restore normal regulation of PRMTs, can inhibit cancer cell growth.
Lab 1 Phone: (614) 247-7441
Lab 2 Phone: (614) 292-7198
Said Sif website |
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Current Publications
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J Cell Physiol 213(2): 306-15, 2008
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Interplay between chromatin remodelers and protein arginine methyltransferases.
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Pal S, Sif S
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Mol Cell Biol 28(20): 6262-77, 2008
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Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells.
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Wang L, Pal S, Sif S
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J Cell Biochem 102(5): 1256-70, 2008
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The mouse C/EBPdelta gene promoter is regulated by STAT3 and Sp1 transcriptional activators, chromatin remodeling and c-Myc repression.
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Zhang Y, Sif S, DeWille J
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