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OSUCCC
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Albert de la Chapelle, M.D., Ph.D.
Professor
College of Medicine
Molecular Virology, Immunology & Medical Genetics - Human Cancer Genetics
804 Biomedical Res. Tower
460 W. 12th Avenue Columbus,OH. 43210
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(614) 688-4781 |
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(614) 688-4763 |
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Programs
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Current Publications
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Cancer Res 69(2): 625-31, 2009
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A susceptibility locus for papillary thyroid carcinoma on chromosome 8q24.
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He H, Nagy R, Liyanarachchi S, Jiao H, Li W, Suster S, Kere J, de la Chapelle A
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Nat Genet 41(4): 460-4, 2009
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Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations.
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Gudmundsson J, Sulem P, Gudbjartsson DF, Jonasson JG, Sigurdsson A, Bergthorsson JT, He H, Blondal T, Geller F, Jakobsdottir M, Magnusdottir DN, Matthiasdottir S, Stacey SN, Skarphedinsson OB, Helgadottir H, Li W, Nagy R, Aguillo E, Faure E, Prats E, Saez B, Martinez M, Eyjolfsson GI, Bjornsdottir US, Holm H, Kristjansson K, Frigge ML, Kristvinsson H, Gulcher JR, Jonsson T, Rafnar T, Hjartarsson H, Mayordomo JI, de la Chapelle A, Hrafnkelsson J, Thorsteinsdottir U, Kong A, Stefansson K
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Fam Cancer in press: , 2009
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Epitope-positive truncating MLH1 mutation and loss of PMS2: implications for IHC-directed genetic testing for lynch syndrome.
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Zighelboim I, Powell MA, Babb SA, Whelan AJ, Schmidt AP, Clendenning M, Senter L, Thibodeau SN, de la Chapelle A, Goodfellow PJ
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28(38): 3345-8, 2009
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Genetic predisposition to human disease: allele-specific expression and low-penetrance regulatory loci.
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de la Chapelle A
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Oncogene 28(38): 3345-8, 2009
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Genetic predisposition to human disease: allele-specific expression and low-penetrance regulatory loci.
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de la Chapelle A
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8(11): 1642-3, 2009
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Genomic sequence matters: a SNP in microRNA-146a can turn anti-apoptotic.
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Jazdzewski K, de la Chapelle A
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Int J Cancer 125(6): 1492-3, 2009
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Identifying Lynch syndrome.
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de la Chapelle A, Palomaki G, Hampel H
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Cancer Res 69(12): 4959-61, 2009
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Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon cancer patients.
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Guda K, Natale L, Lutterbaugh J, Wiesner GL, Lewis S, Tanner SM, Tomsic J, Valle L, de la Chapelle A, Elston RC, Willis J, Markowitz SD
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Cancer Causes Control in press: , 2009
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Low cancer incidence rates in Ohio Amish.
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Westman JA, Ferketich AK, Kauffman RM, Maceachern SN, Wilkins JR 3rd, Wilcox PP, Pilarski RT, Nagy R, Lemeshow S, de la Chapelle A, Bloomfield CD
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Proc Natl Acad Sci U S A 106(5): 1502-5, 2009
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Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer.
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Jazdzewski K, Liyanarachchi S, Swierniak M, Pachucki J, Ringel MD, Jarzab B, de la Chapelle A
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106(5): 1502-5, 2009
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Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer.
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Jazdzewski K, Liyanarachchi S, Swierniak M, Pachucki J, Ringel MD, Jarzab B, de la Chapelle A
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in press: , 2009
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Reply to L.H. Jensen et al and S. Jahn et al.
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Hampel H, Frankel W, de la Chapelle A
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Cancer Res 69(2): 678-86, 2009
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Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development.
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Zeng Q, Phukan S, Xu Y, Sadim M, Rosman DS, Pennison M, Liao J, Yang GY, Huang CC, Valle L, Di Cristofano A, de la Chapelle A, Pasche B
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J Med Genet 45(6): 340-5, 2008
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A frame-shift mutation of PMS2 is a widespread cause of Lynch syndrome.
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Clendenning M, Senter L, Hampel H, Lagerstedt RK, Sun S, Buchanan D, Walsh MD, Nilbert M, Green JS, Potter J, Lindblom A, de la Chapelle A
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J Med Genet 45(12): 827-31, 2008
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A novel mutation in the sulfate transporter gene SLC26A2 (DTDST) specific to the Finnish population causes de la Chapelle dysplasia.
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Bonafé L, Hastbacka J, de la Chapelle A, Campos-Xavier AB, Chiesa C, Forlino A, Superti-Furga A, Rossi A
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J Inherit Metab Dis in press: , 2008
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Amnionless (AMN) mutations in Imerslund-Gräsbeck syndrome may be associated with disturbed vitamin B(12) transport into the CNS.
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Luder AS, Tanner SM, de la Chapelle A, Walter JH
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Cancer Res 67(19): 9603, 2008
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Comment on: Screening for Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) among Endometrial Cancer Patients.
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Hampel H, Panescu J, Lockman J, Sotamaa K, Fix D, Comeras I, LaJeunesse J, Nakagawa H, Westman JA, Prior TW, Clendenning M, de la Chapelle A, Frankel W, Penzone P, Cohn DE, Copeland L, Eaton L, Fowler J, Lombardi J, Dunn P, Bell J, Reid G, Lewandowski G, Vaccarello L
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Proc Natl Acad Sci U S A 105(20): 7269-74, 2008
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Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma.
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Jazdzewski K, Murray EL, Franssila K, Jarzab B, Schoenberg DR, de la Chapelle A
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J Clin Oncol 26(35): 5783-8, 2008
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Feasibility of screening for Lynch syndrome among patients with colorectal cancer.
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Hampel H, Frankel WL, Martin E, Arnold M, Khanduja K, Kuebler P, Clendenning M, Sotamaa K, Prior T, Westman JA, Panescu J, Fix D, Lockman J, Lajeunesse J, Comeras I, de la Chapelle A
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Science 321(5894): 1361-5, 2008
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Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer.
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Valle L, Serena-Acedo T, Liyanarachchi S, Hampel H, Comeras I, Li Z, Zeng Q, Zhang HT, Pennison MJ, Sadim M, Pasche B, Tanner SM, de la Chapelle A
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Blood 111(11): 5371-9, 2008
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High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CALGB) st
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Langer C, Radmacher MD, Ruppert AS, Whitman SP, Paschka P, Mrozek K, Baldus CD, Vukosavljevic T, Liu CG, Ross ME, Powell BL, de la Chapelle A, Kolitz JE, Larson RA, Marcucci G, Bloomfield CD
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Gastroenterology 134(4): 1246-9, 2008
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Immunology and the Lynch syndrome.
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Lynch HT, Drescher KM, de la Chapelle A
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Br J Haematol 139(5): 744-52, 2008
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Molecular profiling of chronic lymphocytic leukaemia: genetics meets epigenetics to identify predisposing genes.
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Plass C, Byrd JC, Raval A, Tanner SM, de la Chapelle A
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Cancer Res 68(7): 2145-53, 2008
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Origins and prevalence of the American Founder Mutation of MSH2.
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Clendenning M, Baze ME, Sun S, Walsh K, Liyanarachchi S, Fix D, Schunemann V, Comeras I, Deacon M, Lynch JF, Gong G, Thomas BC, Thibodeau SN, Lynch HT, Hampel H, de la Chapelle A
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Gastroenterology 135(2): 419-28, 2008
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The clinical phenotype of Lynch syndrome due to germ-line PMS2 mutations.
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Senter L, Clendenning M, Sotamaa K, Hampel H, Green J, Potter JD, Lindblom A, Lagerstedt K, Thibodeau SN, Lindor NM, Young J, Winship I, Dowty JG, White DM, Hopper JL, Baglietto L, Jenkins MA, de la Chapelle A
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J Natl Cancer Inst 100(4): 277-81, 2008
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The frequency of Muir-Torre syndrome among Lynch syndrome families.
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South CD, Hampel H, Comeras I, Westman JA, Frankel WL, de la Chapelle A
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