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OSUCCC
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Samson T. Jacob, Ph.D.
Professor
College of Medicine
Molecular and Cellular Biochemistry
333 Hamilton Hall
1645 Neil Avenue Columbus,OH. 43210
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(614) 688-5494 |
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(614) 688-5600 |
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Programs
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Current Publications
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Cancer Res 69(10): 4277-85, 2009
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A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.
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Datta J, Ghoshal K, Denny WA, Gamage SA, Brooke DG, Phiasivongsa P, Redkar S, Jacob ST
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Mol Endocrinol 23(2): 176-87, 2009
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Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity.
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Ramaswamy B, Majumder S, Roy S, Ghoshal K, Kutay H, Datta J, Younes M, Shapiro CL, Motiwala T, Jacob ST
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J Biol Chem 284(1): 455-64, 2009
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PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells.
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Motiwala T, Majumder S, Ghoshal K, Kutay H, Datta J, Roy S, Lucas DM, Jacob ST
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Hepatology 50(4): 1152-61, 2009
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Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice.
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Wang B, Majumder S, Nuovo G, Kutay H, Volinia S, Patel T, Schmittgen TD, Croce C, Ghoshal K, Jacob ST
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J Biol Chem 283(48): 33394-405, 2008
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Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1.
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Nasser MW, Datta J, Nuovo G, Kutay H, Motiwala T, Majumder S, Wang B, Suster S, Jacob ST, Ghoshal K
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Cancer Res 68(13): 5049-58, 2008
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Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.
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Datta J, Kutay H, Nasser MW, Nuovo GJ, Wang B, Majumder S, Liu CG, Volinia S, Croce CM, Schmittgen TD, Ghoshal K, Jacob ST
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J Biol Chem 283(44): 29897-903, 2008
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MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1.
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Miller TE, Ghoshal K, Ramaswamy B, Roy S, Datta J, Shapiro CL, Jacob S, Majumder S
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J Biol Chem 282(37): 27171-80, 2008
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Treatment of PC12 cells with nerve growth factor induces proteasomal degradation of T-cadherin that requires tyrosine phosphorylation of its cadherin domain.
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Bai S, Datta J, Jacob ST, Ghoshal K
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