|
|
OSUCCC
 |
Michael D. Lairmore, D.V.M., Ph.D.
Assoc. Director for Basic Science
Professor/ Chair
College of Veterinary Medicine
Veterinary Biosciences - Veterinary Biosciences
207 Goss Laboratory
1925 Coffey Road Columbus,OH. 43210
o |
(614) 292-3398 |
f |
(614) 292-6473 |
|
Programs
|
 |
| Dr. Lairmore is a professor and chair of the Department of Veterinary Biosciences in the College of Veterinary Medicine at Ohio State since February 2002. He is trained in molecular virology and veterinary pathology and is a diplomate of both the American College of Veterinary Pathologists and American College of Veterinary Microbiologists.
Lairmore earned his PhD in 1987 from Colorado State University and then performed postdoctoral research at the Centers for Disease Control in Atlanta, Ga., where he became nationally recognized for his studies of human retroviruses.
Human T-lymphotropic virus type 1 (HTLV-1) infection causes adult T cell leukemia/lymphoma (ATL) and a variety of immune-mediated disorders. Lairmore's research seeks to understand mechanisms by which these proteins influence HTLV-1 replication and cellular gene expression during natural infection.
In 1990, he joined The Ohio State University to continue his research. Since then, he has been continuously funded from extramural sources, including a $9.8 million program project grant from the National Cancer Institute entitled "Retroviral Models of Lymphocyte Transformation and Disease." He is a member of the OSUCCC's Viral Oncogenesis Program and the author or co-author of more than 120 publications in scientific journals. |
|
Current Publications
|
|
Microb Pathog 46(6): 306-14, 2009
|
|
Complement protein C3 binding to Bacillus anthracis spores enhances phagocytosis by human macrophages.
|
|
Premanandan C, Storozuk CA, Clay CD, Lairmore MD, Schlesinger LS, Phipps AJ
|
|
|
Vet Pathol 46(5): 1003-14, 2009
|
|
Expression of tumor invasion factors determines systemic engraftment and induction of humoral hypercalcemia in a mouse model of adult T-cell leukemia.
|
|
Machado-Parrula C, Zimmerman B, Nadella M, Shu S, Rosol T, Fernandez S, Lairmore M, Niewiesk S
|
|
|
PLoS One 4(2): e4420, 2009
|
|
Human T cell leukemia virus reactivation with progression of adult T-cell leukemia-lymphoma.
|
|
Ratner L, Harrington W, Feng X, Grant C, Jacobson S, Noy A, Sparano J, Lee J, Ambinder R, Campbell N, Lairmore MD, AIDS Malignancy Consortium
|
|
|
J Virol 83(10): 5232-43, 2009
|
|
Human T-cell leukemia virus type 2 Rex carboxy terminus is an inhibitory/stability domain that regulates Rex functional activity and viral replication.
|
|
Xie L, Kesic M, Yamamoto B, Li M, Younis I, Lairmore MD, Green PL
|
|
|
J Virol 83(22): 11467-76, 2009
|
|
Novel role for interleukin-2 receptor-Jak signaling in retrovirus transmission.
|
|
Taylor JM, Brown M, Nejmeddine M, Kim KJ, Ratner L, Lairmore M, Nicot C
|
|
|
J Vet Med Educ 36(1): 70-5, 2009
|
|
The need for veterinarians in biomedical research.
|
|
Rosol TJ, Moore RM, Saville WJ, Oglesbee MJ, Rush LJ, Mathes LE, Lairmore MD
|
|
|
Cancer Res 67(24): 11859-66, 2008
|
|
A novel bioluminescent mouse model and effective therapy for adult T-cell leukemia/lymphoma.
|
|
Shu ST, Nadella MV, Dirksen WP, Fernandez SA, Thudi NK, Werbeck JL, Lairmore MD, Rosol TJ
|
|
|
Retrovirology 5: 46, 2008
|
|
Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: implications for transformation.
|
|
Nadella MV, Shu ST, Dirksen WP, Thudi NK, Nadella KS, Fernandez SA, Lairmore MD, Green PL, Rosol TJ
|
|
|
Retrovirology 5: 38, 2008
|
|
Human T-cell leukemia virus type 2 post-transcriptional control protein p28 is required for viral infectivity and persistence in vivo.
|
|
Yamamoto B, Li M, Kesic M, Younis I, Lairmore MD, Green PL
|
|
|
Blood 112(9): 3788-97, 2008
|
|
Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation.
|
|
Arnold J, Zimmerman B, Li M, Lairmore MD, Green PL
|
|
|
Blood 113(7): 1493-500, 2008
|
|
Imaging spontaneous tumorigenesis: inflammation precedes development of peripheral NK tumors.
|
|
Rauch D, Gross S, Harding J, Niewiesk S, Lairmore M, Piwnica-Worms D, Ratner L
|
|
|
Cancer Res 68(14): 5512-8, 2008
|
|
XXIII International Association for Comparative Research on Leukemia and Related Diseases Symposium: from molecular pathogenesis to targeted therapy in leukemia and solid tumors.
|
|
Hackanson B, Becker H, Berg T, Binder M, Dierks C, Duque-Afonso J, Lairmore MD, Schäfer HS, Schnitzler M, Zeiser R, Martens U, Mertelsmann R, Lübbert M
|
|
|
