The OSUCCC Pharmacoanalytical Shared Resource (PhASR) is a decentralized facility currently housed in the College of Pharmacy, room 241 Parks Hall and room 151 Riffe. Two state-of-the art LC/MS systems are available for quantitation of analytes and identification of metabolites in biological matrices. A highly sensitive ThermoFinnigan TSQ Quantum Discovery Max triple quadrupole mass spectrometer coupled to an Agilent 1100 LC system, complete with binary pump, micro-well plate autosampler and UV detector, is available in room 241 Parks Hall. A ThermoFinnigan TSQ Quantum Discovery Max EMR coupled to a Shimadzu Prominence HPLC system is available in room 151 Riffe. Primary use of this equipment will be for the quantitation of parent drug and metabolites in clinical specimens. The PhASR also supports pre-clinical investigation by quantifying analytes in biological samples from animals (tissue, plasma, urine, feces), cell or tissue cultures, and other in vitro systems. The LC/MS systems in the PhASR can also be used for drug metabolite or degradation product identification. Due to its location in the fully equipped research laboratories of Dr. James T. Dalton and Dr. Kenneth K. Chan, the PhASR has the resources necessary to develop and run biological correlative assays. The staff of the PhASR has expertise in pharmacology, bioanalytical methodology and pharmacokinetics and is available for consultation on clinical or pre-clinical PK/PD experimental design and analysis.