Publications (selected)
microRNA Signature in Lung Cancer Diagnosis and Prognosis
Nozomu Yanaihara, Natasha Caplen, Elise Bowman , Kensuke Kumamoto, Aikou Okamoto, Jun Yokota , Tadao Tanaka, George Adrian Calin, Chang-Gong Liu , Carlo M. Croce and Curtis C. Harris, 2005, Cancer Cell , In Press
A microRNA expression signature of human solid tumors defines cancer gene targets
Stefano Volinia, George Calin, Chang-Gong Liu , Stefan Ambs, Amelia Cimmino, Fabio Petrocca, Rosa Visione, Marilena Iorio, Claudia Roldo, Manuela Ferracin, Robyn L. Prueitt, Nozumu Yanaihara, Giovanni Lanza, Aldo Scarpa, Andrea Vecchione, Massimo Negrini, Curtise Harris, & Carlo Croce. 2006, PNAS , 2006 February 14, 103(7):2257-2261
The Role of MicroRNA Genes in Papillary Thyroid Cancer
Huiling He, Krystian Jazdzewski, Wei Li, Sandya Liyanarachchi, Rebbecca Nagy, Stefano Volinia, George Calin, Chang-Gong Liu , Kaaarle Franssila, Saul Suster, Richard T. Kloos, Carlo Croce and Albert de la Chapelle . 2005. PNAS , 2005 Dec 27;102(52):19075-80. Epub 2005 Dec 19
MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemia cell growth via receptor downmodulation
Felli N., Fontana L., Pelosi E., Botta R., Bonci D., Facchiano F., Liuzzi F., Lulli V., Morsilli O., Santoro S., Valtieri M.,Calin G. A., Liu C-G., Sorrentino A., Croce C.M., Peschle C. 2005 PNAS , 2005 Dec.13, 102(50) pp18081-18086.
A unique microRNA signature associated with prognostic factors and disease progression in B cell Chronic Lymphocytic Leukemia
George Calin, Manuela Ferracin, Amelia Cimmino, Gianpiero Di Leva, Masaoshi Shimizu, Sylwia Wojcik, Marilena Iorio, Rosa Visione, Nuretin Ilfer Sever, Muller Fabbri, Rodolf Iuliano, Tiziana Palumbo, Flavia Pichiorri, Claudia Roldo, Ramiro Garzon, Cinzia Sevignani, Laura Rassenti, Hanjerg Alder, Stefano Volinia, Chang-gong Liu, Thomas J. Kipps, Massimo Negrini, and Carlo M Croce. 2005, N Engl J Med. 353(17), pp21-29
miR-15 and miR-16 induce apoptosis by targeting BCL2.
Cimmino A , Calin GA , Fabbri M , Iorio MV , Ferracin M , Shimizu M , Wojcik SE , Aqeilan RI , Zupo S , Dono M , Rassenti L , Alder H , Volinia S , Liu CG , Kipps TJ , Negrini M , Croce CM . Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13944-9.
Extensive modulation of a set of microRNAs in primary glioblastoma
Silvia Anna Ciafre, Silvia Galardi, Annuniato Mangiola, Chang-gong Liu, Giovanni Sabatino, Manuela Ferracin, Giulio Maira, Carlo Croce, Maria Giulia Farace, 2005, Biochemical and Biophysical Research Communications, 334, pp1351-1358
Modulation of Gene Expression in Precancerous Rat Esophagus by Dietary Zinc Deficit and Replenishment.
Chang-gong Liu, Liang Zhang, Yubao Jiang, Devjani Chatterjee, Carlo Croce, Kay Huebner and Louise Y.Y. Fong. 2005. Cancer Research. 65(17), September, pp7790-7799
MicroRNA Gene Expression Deregulation in Human Breast Cancer.
Marilena V. Iorio;, Manuela Ferracin, Chang-gong Liu, Angelo Veronese, Riccardo Spizzo, Silvia Sabbioni, Eros Magri, Massimo Pedriali, Muller Fabbri, Manuela Campiglio, Sylvie Menard, Anne Rosenberg, Stefano Volinia, Italo Nenci, George Calin, Patrizia Querzoli, Massimo Negrini, Carlo Croce. 2005, Cancer Research, Aug 15;65(16):7065-70
A germline stop mutation in ARLTS1 , a new member of the ADP-ribosylation factor family is associated with familial cancers and reduced in vivo apoptosis. Calin, G.A., Trapasso, F., Shimizu, M., Dumitru, C.D., Cesari,, R., Yendamuri, S., Godwin, A.K., Ferracin, M., Bernardi, G., Chatterjee, D., Baldassarre, G., Rattan, S., Alder, H., Mabuchi, H., Shiraishi, T., Lotte, L., Vlad Herlea, H., Mauro, F., Dighiero, G., Movsas, B., Rassenti, L., Kipps, T., Baffa, R., Fusco, A., Mori, M., Russo, G., Liu, C.G . , Neuberg, D., Bullrich, F., Negrini, M. and Croce, C. 2005. N Engl J Med. 2005 Apr 21;352(16):1667-76
An oligonucleotide microchip for genome-wide miRNA profiling in human and mouse tissues. Liu, C.G. , Calin, G.A., Meloon, B., Gamliel, N., Sevignani, C., Ferracin, M., Dumitru, C.D., Shimizu , M., Zupo, S., Dono, M., Alder, H., Bullrich, F., Negrini, M. and Croce, C. 2004, Proc. Natl. Acad. Sci. USA, 101:9740-9744, 2004
MicroRNA profiling reveals distinct signatures in B-cell chronic lymphocytic leukemias.
Calin, G.A., Liu, C.G., Sevignani, C., Ferracin, M., Felli, N., Dumitru, C.D., Shimizu , M., Cimmino, A., Zupo, S., Dono, M., Del'Aquila, M.L., Alder, H., Rassenti, L., Kipps, T.J., Bullrich, F., Negrini, M. and Croce,C.M. 2004, MicroRNA profiling reveals distinct signatures in B-cell chronic lymphocytic leukemias. Proc. Natl. Acad. Sci. USA, . 2004 Aug 10;101(32):11755-60 .
Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics . Virtaneva K, Wright FA, Tanner SM, Yuan B, Lemon WJ, Caligiuri MA, Bloomfield CD, de la Chapelle A and Krahe R.. (2001) Proc.Natl.Acad.Sci.USA 98, 1124-1129.
Gene expression in papillary thyroid carcinoma reveals highly consistent profiles. Huang Y, Prasad M, Lemon WJ, Hampel H, Wright FA, Kornacker K, LiVolsi V, Frankel W, Kloos RT, Eng C, Pellegata NS and de la Chapelle A. (2001) Proc.Natl.Acad.Sci.USA 98, 15044-15049.
Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. Lemon, WJ, Bernert H, Sun H Wang Y and You M. (2002) J.Med.Genet. 39:644-655.
Theoretical and experimental comparisons of gene expression indexes for oligonucleotide arrays. Lemon WJ, Palatini JT, Krahe R and Wright FA. (2002) Bioinformatics 18: 1470-1476.
Single nucleotide polymorphism (SNP) analysis of mouse pulmonary adenoma susceptibility loci 1-4 for identification of candidate genes. Lemon WJ, Swinton CH, Wang M, Berbari N, Wang Y, You M (2003) J.Med.Genet. 40:e36.
Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53. Yoon H, Liyanarachchi S, Wright FA, Davuluri R, Lockman JC, de la Chapelle A, Pellegata NS (2002) Proc.Natl.Acad.Sci.USA 99,15632-15637.
